What is Advair Diskus?

Advair Diskus

Advair Diskus generic name Fluticasone Propionate, Advair HFA (cont.)
Advair contains a mixture of salmeterol, a bronchodilator of the beta-2 agonist type, and fluticasone propionate, an anti-inflammatory corticosteroid. Beta-2 agonists are medicines that are attached to beta-2 receptors on the smooth muscle cells that are around the airways, which cause the muscle cells to calm and open the airways. Fluticasone propionate is a synthetic (manmade) corticosteroid of the glucocorticoid family that is associated with the natural hormone, cortisol or hydrocortisone, made by the adrenal glands.

Glucocorticoid steroids include potent anti-inflammatory actions. In asthmatic people, the suppression of swelling within the airways decreases the inflammation caused by swelling that narrows the airways. Simultaneously, production of mucus is decreased. When utilized in reduced doses, minimal inhaled fluticasone propionate is passed into the body and side effects are irregular. When increased doses are recommended, fluticasone is absorbed and might cause side effects somewhere else in your body. The FDA authorized Advair Diskus in August, 2000 and Advair HFA in June 2006.

How to use advair diskus: Advair Diskus can be used for the treatments for asthma or chronic obstructive pulmonary disease (COPD) related to chronic bronchitis. Its action begins within 30 to 60 minutes and can last above 12 hours. Advair Diskus is typically not being used in patients whose asthma may be controlled very easily with irregular administration of short acting inhalers. Advair HFA is utilized for the treatment of asthma in people 12 years old or older. Advair Diskus or HFA ought not to be used to cure serious attacks of asthma or COPD.

Advair Diskus SIDE EFFECTS

SIDE EFFECTS: Higher respiratory tract illness occurs in 20% to 25% of patients making use of Advair. Headaches occurs mostly to about 1 in 8 people that frequently utilize it . Other possible adverse events include
• Nausea,
• vomiting,
• Diarrhea,
• Mouth or throat candidiasis, and
• Musculoskeletal ache.

Usage of long acting agents like salmeterol, an active ingredient in Advair, might raise the danger of asthma-related death. For that reason, Advair ought to only be used in people whose asthma is uncontrolled by other agents, and which are making use of long term asthma-controlling medicines for example an inhaled corticosteroid.
Doctor prescribed: Yes
GENERIC AVAILABLE: No
PREPARATIONS: Advair Diskus is an oral inhalation powder obtainable in three different types containing the similar quantity of salmeterol, 50 mcg, however different in the quantity of fluticasone propionate. 100/50 offers 100 mcg of fluticasone propionate, 250/50 provides 250 mcg of fluticasone propionate, and 500/50 includes 500 mcg of fluticasone propionate per inspiration.

Advair HFA is an oral aerosol including 21 mcg of salmeterol mixed with 45, 115, or 230 mcg fluticasone.

STORAGE

STORAGE: Advair ought to be stored at room temperature, 68 F to 77 F (20 C to 25 C). It ought to be put away from high temperature or flames and must not be punctured; it ought to not be frozen or put in direct sunlight.

Advair Diskus Dosage

DOSING : The suggested Advair Diskus routine for asthma in people 12 years and older is one inhalation 2 times every day ( morning and evening ) around 12 hours apart . The minimum effective strength needs to be used and the highest dose is 500/50 mcg two times every day. For the children 4 to 11 years old the suggested medication is one inhalation of 100/50 mcg two times every day. The suggested routine of Advair Diskus for COPD is one inhalation of 250/50 mcg two times every day. Increased doses are not more effective.
The suggested dose for Advair HFA is 2 inhalations two times every day. The minimum effective dose needs to be used.

The Diskus device is held in a single hand with the thumb other hand put on the thumb-grip. The thumb is then simply pulled away as far as the device permits until the mouthpiece appears to click into place. With the Diskus then kept horizontally and with the mouthpiece in the direction of the patient, the lever is then slid away as far as it could go until it clicks. The person breathes out as far as relaxing, and then putting his mouth to the mouthpiece, breathes in instantly and deeply and keeps his breath for around ten seconds. The person then washes his or her mouth area without swallowing after inhalation.

DRUG INTERACTIONS:

Monoamine oxidase inhibitors (for example, tranylcypromine) and tricyclic antidepressants (for example, amitriptyline Endep) might raise the effect of salmeterol on the heart and blood pressure level. Since Advair includes salmeterol, it ought to not be utilized with or within two weeks of ending monoamine oxidase inhibitors or tricyclic antidepressants.

 

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