Aricept (Donepezil Hydrochloride)
ARICEPT is a reversible inhibitor of the enzyme acetyl cholinesterase , well known chemically as ( ± )-2 , 3-dihydro-5 , 6-dimethoxy-2-1-( phenyl methyl )-4-piperidinylmethyl-1H-inden-1-one hydrochloride . Donepezil hydrochloride is usually known in the pharmacological literature as E2020. It includes an empirical formula of C24H29NO3HCl along with a molecular weight of 415 .96. Donepezil hydrochloride is a white crystalline powder which is easily soluble in chloroform, soluble in water and in glacial acetic acid, fairly soluble in ethanol and in acetonitrile and also almost insoluble in ethyl acetate and in n-hexane.
What is aricept used for?
ARICEPT can be obtained for oral administration in film-coated tablets that contains 5, 10, or 23 mg of donepezil hydrochloride.
Non-active ingredients in 5 mg and 10 mg tablets are lactose monohydrate, corn starch, microcrystalline cellulose, hydroxypropyl cellulose, and also magnesium stearate. The film covering consists of talc, polyethylene glycol, hypromellose and titanium dioxide. In addition, the 10 mg tablet consists of yellow iron oxide (synthetic) as a coloring agent.
Non-active ingredients in 23 mg tablets consist of ethyl cellulose, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate and also methacrylic acid copolymer, Type C. The film coating contains ferric oxide, hypromellose 2910, polyethylene glycol 8000, talc and also titanium dioxide.
ARICEPT ODT tablets can be obtained for oral administration. Every ARICEPT ODT tablet consists of 5 or 10 mg of donepezil hydrochloride. Inactive ingredients are carrageenan, mannitol, colloidal silicon dioxide and also polyvinyl alcohol. In addition, the 10 mg tablet consists of ferric oxide (yellow) as a colors agent.
Aricept medication, has to be taken as recommended, even though you feel right, to give good results. If you experience sleep issues, your physician might change you to a morning dose.
Before having to take Aricept, seek advice from your doctor in case you are pregnant or breastfeeding your baby, or if you are intending to have surgery, including dental surgery.
Aricept needs to be used with care by patients who also experience cardiac disease, asthma, serious cardiac arrhythmias, and chronic obstructive pulmonary disease (COPD), so seek advice from your doctor before making use of.
Always inform your doctor in case your symptoms worsen.
Aricept Side Effects
Aricept (Donepezil Hydrochloride) – Side Effects
Less severe side effects include:
• Loss of desire for food
• Weight loss
• Frequent urination
• Muscle cramps, painful and inflamed joints
• Excessive weariness
• Difficulty getting to sleep
• Headache, anxiousness, nausea
• Depression, mood swings
• Vivid hopes and dreams
More severe side effects might need quick emergency medical attention and include:
• Chest pain
• Difficulty with urination
• Swelling of the tongue, throat, or face
• Severe anemia
• Slow heartbeat
• Breathing issues
• Worsening tummy pain
• Black or bloody stools
• Bloody vomit
Aricept (Donepezil Hydrochloride) Dosage
ARICEPT ought to be taken in the evening, just before settling down for the night.
ARICEPT may be taken with or without meals.
The 23 mg tablet ought not to be separating, smashed or chewed simply because this might increase its rate of absorption.
Permit ARICEPT ODT to melt on the tongue and follow with water.
Gentle to Moderate Alzheimer’s Disease
The dosages of ARICEPT proven to give good results in controlled medical tests are 5 mg and 10 mg administered once daily.
The higher dosage of 10 mg failed to provide a statistically significantly greater medical benefit than 5 mg. There is certainly a recommendation , however , based upon order of group mean scores and dosage trend analyses of data from the medical tests , that an everyday dose of 10 mg of ARICEPT may provide extra benefit for certain patients . Accordingly, whether or not to make use of a dose of 10 mg is dependent on prescriber and patient choice.
Symptoms And Usage
ARICEPT is indicated for the therapy of dementia of the Alzheimer’s type. Effectiveness continues to be shown in patients with mild, moderate, and serious Alzheimer’s disease.