What is Zofran?

Zofran

Zofran is the medicine ondanstetron brand name, a prescription drug used in the treatment or prevention of vomiting or nausea. Zofran is prescribed to treat vomiting and nausea that may result from surgery or those drugs used in the treatment of cancer for example radiation or chemotherapy. Zofran is meant for only preventing vomiting or nausea caused by surgery and cancer treatment. It can also help in the prevention of the common complication of shivering in individuals who have suffered from anesthesia.

Though Zofran has not been approved for treating vomiting and nausea as a result of morning sickness in pregnant women some doctors prescribe off-label Zofran to them. Zofran works by preventing a natural substance found in the brain called serotonin that may increase the risk of vomiting and nausea. Zofran belong to a drug class known as 5-HT3 receptor antagonists. These medications are referred to as antiemetics, this means they block vomiting and nausea. Zofran can come in form of a fast dissolving tablet called Zofran odt. If you will be taking the Zofran odt do not take out the drug from its foil pocket till moments before you take it.

Do not take Zofran if you have allergies for ondansetron or to medications that are similar like palonosetron (Aloxi), granisetron (Kytril), or dolasetron (Anzemet). Do not take this drug if you are using a drug known as apomorphine (Apokyn). The phenylalanine may be contained in the orally disintegrating tablets of Zofran. Tell your health officer if you are suffering from phenylketonuria (PKU). Individuals with underlying heart problems, like long QT syndrome, are already at the risk of having torsade de pointes. Zofran intake may increase this risk. Also tell your doctor if you have ever experienced:
Liver disease
History of congestive failure
Inherited PKU, phenylketonuria
Low potassium or low magnesium

Problems of heart rhythm including the congenital long QT syndrome
There are few proofs that show that taking Zofran during pregnancy is not safe due to the risk of birth defects. Although the drug has been detected in the breast milk of laboratory animals, health experts can’t say if Zofran will pass into breast milk. Always tell your doctor if you plan to get pregnant or already pregnant before you start taking Zofran because of the risk associated with it. The Zofran generic version is available under various brand names, it is therefore very important to be careful when buying any Zofran equivalent.

Side effects of Zofran

These are some of the common Zofran side effects. They include:
Drowsiness, dizziness
Headache
Constipation
Hiccups
Diarrhea
Fatigue
Flushing

Some of the Zofran side effects are more serious than others. If you experience any of these serious side effects of Zofran stop taking the pill immediately and contact your doctor. They are:
Loss of consciousness
Dark-colored urine
Yellowing of eyes or skin, jaundice
Difficulty swallowing, talking or breathing
Seizure
Blurred vision
Pounding or fast heart beats
Loss of coordination
Overactive reflexes
Hallucinations
Diarrhea

This is not a full list of all the side effects that may occur, there are others not included here.

Zofran dosage

Take Zofran just the same way your doctor prescribes it. Follow every direction on the label of your prescription. Do not take this drug longer than was recommended neither should you take smaller or larger quantity of it than was prescribed. Zofran can be taken without food or with food.

Your Zofran dose will be determined by your condition. Zofran is available in 4 and 8 mg or milligram tablets. Zofran ODT is available in 8mg and 4mg tablets that are orally disintegrated. Zofran is also available in liquid forms. To prevent or treat vomiting or nausea, you will normally take one tablet 30minutes before the start of chemotherapy
1 or 2 hours before the commencement of radiation therapy
1 hour before the surgery begin.

You may require more doses of Zofran up to 3 times daily during the treatment or for some days after the cancer treatment.
In a radiation therapy: a normal Zofran dose is 24mg everyday
In chemotherapy: a normal adult dose can be between 16 mg to 24 mg everyday.

To prevent vomiting and nausea after a surgery: a normal Zofran dose is 16 mg before the start of the surgery
In case of Zofran overdose, contact your doctor or call the nearest poison control center. If you miss a dose, take the missed dose immediately you remember. Do not take an extra dose to make up for a missed one.

 

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